We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
An immune-enhancing water-soluble α-glucan from Chlorella vulgaris and structural characteristics.
- Authors
Tabarsa, Mehdi; Shin, Il-Shik; Lee, Ju; Surayot, Utoomporn; Park, WooJung; You, SangGuan
- Abstract
Water-extractable polysaccharides obtained from Chlorella vulgaris were fractionated using anion-exchange chromatography to investigate molecular characteristics and biological activities. Crude and fractionated polysaccharides F, F, and F mostly consisted of carbohydrates (40.0-64.7%), proteins (18.3-31.0%), ash (4.10-16.6%), and uronic acids (1.02-7.30%). Monosaccharide constituents were predominantly glucose (83.9-100%) with small amounts of xylose (10.8-16.1%). Crude polysaccharide and fractions contained 1 or 2 sub-fractions with average M values ranging from 19.7 to 1,145×10 g/mol. Fractions F, F, and F stimulated RAW264.7 cells, inducing release of NO, PGE, and the inflammatory cytokines TNF-α, IL-6, and IL-10. The biologically active part of the immune-enhancing fraction (F) was mainly connected via 1,6-linked glucose with branches at C-3 positions.
- Publication
Food Science & Biotechnology, 2015, Vol 24, Issue 6, p1933
- ISSN
1226-7708
- Publication type
Article
- DOI
10.1007/s10068-015-0255-0