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- Title
The Impact of Vitamin D in Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study in Patients with Morbid Obesity.
- Authors
Borges-Canha, Marta; Neves, João Sérgio; Mendonça, Fernando; Silva, Maria Manuel; Costa, Cláudia; Cabral, Pedro M; Guerreiro, Vanessa; Lourenço, Rita; Meira, Patrícia; Salazar, Daniela; Ferreira, Maria João; Pedro, Jorge; Leite, Ana Rita; von-Hafe, Madalena; Vale, Catarina; Viana, Sara; Sande, Ana; Belo, Sandra; Lau, Eva; Freitas, Paula
- Abstract
Purpose: We aimed to evaluate the association between vitamin D status and hepatic function parameters and scores: Fatty Liver Index (FLI, predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis) in patients with morbid obesity. Patients and Methods: Cross-sectional study including patients with morbid obesity followed in our centre between January 2010 and July 2018. Patients with missing vitamin D levels or hepatic profile parameters were excluded. We divided the population according to two cut-offs of vitamin D levels (12ng/mL and 20ng/mL). Results: The included population (n=1124) had an average age of 43.3± 10.7 years and 84.3% were female. Seventy-point eight percent of the population had vitamin D levels lower than 20ng/mL and 34.8% lower than 12ng/dL. Patients with lower vitamin D levels (< 12ng/mL) had higher BMI, hip and waist circumferences and higher prevalence of hypertension. Higher FLI scores [OR= 0.77 (0.07), p< 0.01] and ALP levels [β= − 0.03 (− 0.06, − 0.01), p< 0.01] associated to lower vitamin D levels. Conclusion: Vitamin D deficiency is associated with a higher risk of hepatic steatosis in individuals with morbid obesity. Correction of vitamin D deficiency may have a beneficial role in the management of NAFLD in patients with morbid obesity.
- Subjects
MORBID obesity; NON-alcoholic fatty liver disease; VITAMIN D; VITAMIN D deficiency; CROSS-sectional method; HEPATIC fibrosis
- Publication
Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2021, Vol 14, p487
- ISSN
1178-7007
- Publication type
Article
- DOI
10.2147/DMSO.S286334