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- Title
Oxidative stress in proliferative parathyroid lesions.
- Authors
Deska, Mariusz; Romuk, Ewa; Segiet, Oliwia Anna; Polczyk, Joanna; Buła, Grzegorz; Gawrychowski, Jacek
- Abstract
Background: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders and defined as excessive secretion of parathormone. PHPT is a risk factor of several cardiovascular diseases, which could be caused by alterations in the oxidant-antioxidant balance. Materials and methods: Our study material constituted of blood serum collected from 52 consecutive patients with PHPT treated surgically, whereas 36 healthy volunteers were our control group. Oxidative stress was evaluated in both patients and control subjects by assessment of malondialdehyde (MDA) and lipid hydroperoxides (LHP). Antioxidants were evaluated by measurement of superoxide dismutase (SOD), ceruloplasmin (CER), catalase (CAT), sulfhydryl (SH) groups, glutathione (GSH), glutathione peroxidase (GSH-Px), Glutathione-S-transferase (GST) activity (GST) and glutathione reductase (GR). Moreover, total antioxidant capacity (TAC) and total oxidative status (TOS) were measured and oxidative stress index (OSI) was calculated. Results: OSI was increased in patients with PHPT when compared to normal controls, whereas TAC was lower in PHPT. Levels of CER, MnSOD, GR, SH groups and MDA were significantly decreased in PHPT. Levels of LHP, catalase and SOD in serum were significantly higher in patients with PHPT than in healthy patients. Erythrocyte CAT activity and GST were significantly increased in patients after parathyroidectomy. Erythrocyte GR and GPx were upregulated postoperatively, whereas SOD activity decreased. Conclusions: In PHPT, there are several alterations in the balance between production of reactive oxygen species and antioxidant defense system.
- Subjects
OXIDATIVE stress; OXIDANT status; GLUTATHIONE reductase; CARDIOVASCULAR diseases risk factors; GLUTATHIONE peroxidase
- Publication
Polish Journal of Surgery, 2019, Vol 91, Issue 1, p29
- ISSN
0032-373X
- Publication type
Article
- DOI
10.5604/01.3001.0012.7792