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- Title
Rationale for MYC imaging and targeting in pancreatic cancer.
- Authors
Schneider, Günter; Wirth, Matthias; Keller, Ulrich; Saur, Dieter
- Abstract
The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The development and successful implementation of precision oncology in other gastrointestinal tumor entities point to opportunities also for PDAC. Therefore, markers linked to specific therapeutic responses and important subgroups of the disease are needed. The MYC oncogene is a relevant driver in PDAC and is linked to drug resistance and sensitivity. Here, we update recent insights into MYC biology in PDAC, summarize the connections between MYC and drug responses, and point to an opportunity to image MYC non-invasively. In sum, we propose MYC-associated biology as a basis for the development of concepts for precision oncology in PDAC.
- Subjects
PANCREATIC cancer; GASTROINTESTINAL tumors; DEVELOPMENTAL biology; DRUG resistance; ONCOGENES
- Publication
EJNMMI Research, 2021, Vol 11, Issue 1, p1
- ISSN
2191-219X
- Publication type
Article
- DOI
10.1186/s13550-021-00843-1