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- Title
Exploration of isoxanthohumol bioconversion from spent hops into 8-prenylnaringenin using resting cells of Eubacterium limosum.
- Authors
Moens, Esther; Bolca, Selin; Van de Wiele, Tom; Van Landschoot, Anita; Goeman, Jan L.; Possemiers, Sam; Verstraete, Willy
- Abstract
Hops is an almost unique source of the potent phytoestrogen 8-prenylnaringenin (8-PN). As hops contain only low levels of 8-PN, synthesis may be more attractive than extraction. A strain of the Gram-positive Eubacterium limosum was isolated previously for 8-PN production from more abundant precursor isoxanthohumol (IX) from hops. In this study, spent hops, an industrial side stream from the beer industry, was identified as interesting source of IX. Yet, hop-derived compounds are well-known antibacterial agents and the traces of a large variety of different compounds in spent hops interfered with growth and IX conversion. Critical factors to finally enable bacterial 8-PN production from spent hops, using a food and feed grade medium, were evaluated in this research. The use of bacterial resting cells and complex medium at a pH of 7.8–8 best fulfilled the requirements for 8-PN production and generated a solid basis for development of an economic process.
- Subjects
EUBACTERIALES; BIOCONVERSION; HOPS; BEER industry; BACTERIAL cells; PHYTOESTROGENS
- Publication
AMB Express, 2020, Vol 10, Issue 1, p1
- ISSN
2191-0855
- Publication type
Article
- DOI
10.1186/s13568-020-01015-5