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- Title
Bortezomib: an effective agent in extramedullary disease in multiple myeloma.
- Authors
Rosiñol, Laura; Cibeira, Ma. Teresa; Uriburu, Carla; Yantorno, Sebastián; Salamero, Olga; Bladé, Joan; Montserrat, Emili
- Abstract
Bortezomib is a potent and selective proteasome inhibitor recently introduced in the treatment of multiple myeloma (MM). This drug produces significant responses in about one-third of patients with relapsed/refractory disease. We first recognized the lack of efficacy of thalidomide in soft-tissue plasmacytomas. There is little information on the effect of bortezomib on extramedullary myeloma. Four of 23 patients treated with bortezomib at our institution had extramedullary involvement at the time of relapse. In three of these patients large soft-tissue plasmacytomas disappeared. This indicates that bortezomib may be useful in clinical situations of extramedullary disease in which other agents, such as thalidomide, may not be effective.
- Subjects
PHARMACEUTICAL research; THERAPEUTICS; MEDICAL care; MULTIPLE myeloma; BLOOD diseases; THALIDOMIDE; PLASMACYTOMA; MEDICAL research
- Publication
European Journal of Haematology, 2006, Vol 76, Issue 5, p405
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/j.0902-4441.2005.t01-1-EJH2462.x