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- Title
Oxidized Low Density Lipoprotein Induced Caspase-1 Mediated Pyroptotic Cell Death in Macrophages: Implication in Lesion Instability?
- Authors
Lin, Jing; Shou, Xiling; Mao, Xiaobo; Dong, Jiangchuan; Mohabeer, Nilesh; Kushwaha, Kishan kumar; Wang, Lei; Su, Yousu; Fang, Hongcheng; Li, Dazhu
- Abstract
Background: Macrophage death in advanced lesion has been confirmed to play an important role in plaque instability. However, the mechanism underlying lesion macrophage death still remains largely unknown. Methods and Results: Immunohistochemistry showed that caspase-1 activated in advanced lesion and co-located with macrophages and TUNEL positive reaction. In in-vitro experiments showed that ox-LDL induced caspase-1 activation and this activation was required for ox-LDL induced macrophages lysis, IL-1β and IL-18 production as well as DNA fragmentation. Mechanism experiments showed that CD36 and NLRP3/caspase-1/pathway involved in ox-LDL induced macrophage pyroptosis. Conclusion: Our study here identified a novel cell death, pyroptosis in ox-LDL induced human macrophage, which may be implicated in lesion macrophages death and play an important role in lesion instability.
- Subjects
LOW density lipoproteins; CASPASES; MACROPHAGES; CELL death; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; MOLECULAR biology
- Publication
PLoS ONE, 2013, Vol 8, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0062148