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- Title
Immunohistochemical Characterization of Feline Mast Cell Tumors.
- Authors
Mallett, C. L.; Northrup, N. C.; Saba, C. F.; Rodriguez, C. O.; Rassnick, K. M.; Gieger, T. L.; Childress, M. O.; Howerth, E. W.
- Abstract
Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.
- Subjects
CAT diseases; CANCER in animals; ONCOLOGY; HISTAMINE; SEROTONIN; IMMUNOHISTOCHEMISTRY
- Publication
Veterinary Pathology, 2013, Vol 50, Issue 1, p106
- ISSN
0300-9858
- Publication type
Article
- DOI
10.1177/0300985812441032