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- Title
Kidney function and markers of inflammation in elderly persons without chronic kidney disease: The health, aging, and body composition study.
- Authors
Keller, C. R.; Odden, M. C.; Fried, L. F.; Newman, A. B.; Angleman, S.; Green, C. A.; Cummings, S. R.; Harris, T. B.; Shlipak, M. G.
- Abstract
Inflammatory markers are elevated in persons with estimated glomerular filtration rates less than 60 ml/min/1.73 m2. As cystatin C may detect small changes in kidney function not detected by estimated glomerular filtration rate, we evaluated the association between cystatin C and serum markers of inflammation in older adults with estimated glomerular filtration rate 60. This is an analysis using measures from the Health, Aging, and Body Composition Study, a cohort of well-functioning adults aged 70–79 years. Cystatin C correlated with all five inflammatory biomarkers: C-reactive protein (r=0.08), interleukin-6 (r=0.19), tumor necrosis factor α (TNF-α) (r=0.41), soluble TNF receptor 1 (STNF-R1) (r=0.61), and soluble TNF receptor 2 (STNF-R2) (r=0.54); P<0.0005 for all. In adjusted analyses, cystatin C concentrations appeared to have stronger associations with each biomarker compared with estimated glomerular filtration rate or serum creatinine. Participants with a cystatin C1.0 mg/l had significantly higher levels of all five biomarkers compared to those with a cystatin C<1.0 (mean differences ranging 16–29%, all P<0.05). Cystatin C has a linear association with inflammatory biomarkers in an ambulatory elderly cohort with estimated glomerular filtration rates 60; associations are particularly strong with TNF-α and the STNF-R.Kidney International (2007) 71, 239–244. doi:10.1038/sj.ki.5002042; published online 20 December 2006
- Subjects
GLOMERULAR filtration rate; INFLAMMATION; DISEASES in older people; KIDNEY diseases; BIOMARKERS; C-reactive protein; CREATININE; TUMOR necrosis factors
- Publication
Kidney International, 2007, Vol 71, Issue 3, p239
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/sj.ki.5002042