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- Title
ARG1 Is a Potential Prognostic Marker in Metastatic Endometrial Cancer.
- Authors
Tran, Dinh Nam; Rozen, Valery; Nguyen, Loan Thi Kim; Jung, Jin-Seok; Coghill, Lyndon M.; Hunter, Mark I.; Kim, Tae Hoon; Yoo, Jung-Yoon; Jeong, Jae-Wook
- Abstract
Endometrial cancer (EC) is the most common gynecologic malignancy. While the majority of patients present with early-stage and low-grade EC and have an excellent prognosis, a subset has metastatic disease at presentation or develops distant recurrence after initial treatment of the primary. However, the lack of prognostic biomarkers for metastatic EC is a critical barrier. Arginase 1 (ARG1) regulates the last step of the urea cycle, and an increase in ARG1 has been correlated as a poor prognostic factor in a variety of cancers. In the present study, ARG1 expression was evaluated as a potential prognostic marker for metastatic EC in endometrial hyperplasia and cancer of mice with Pten mutation as well as Pten and Mig-6 double mutations. While Pten mutation in the uterus is not sufficient for distant metastasis, mice with concurrent ablation of Mig-6 and Pten develop distant metastasis. Our immunostaining and RT-qPCR analysis revealed that the expression of ARG1 in early stage of EC as well as endometrial hyperplasia from mice deficient in Mig-6 and Pten mutations significantly increased compared to Pten mutation in the uterus. The results suggest that a high level of ARG1 is associated with poor prognosis in association with EC of mouse.
- Publication
Reproductive Sciences, 2024, Vol 31, Issue 6, p1632
- ISSN
1933-7191
- Publication type
Article
- DOI
10.1007/s43032-024-01493-z