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- Title
Distribution of Infecting Hepatitis C Virus Genotypes in End-Stage Liver Disease Patients at a Large American Transplantation Center.
- Authors
Vargas, Hugo E.; Wang, Lian-Fu; Laskus, Tomasz; Poutous, Anthony; Lee, Randall; Demetris, Anthony; Dodson, Forrest; Casavilla, Adrian; Fung, John; Gayowski, Timothy; Singh, Nina; Marino, Ignazio; Rakela, Jorge
- Abstract
The distribution of hepatitis C virus (HCV) genotypes was studied in 202 anti-HCV-positive liver transplant candidates with end-stage liver disease. HCV sequences were successfully amplified from 185 patients: In the first 100, the genotype was determined by direct sequencing in the NS5 region, and in the remaining 85, type-specific primers were used for genotyping. Eighty-five patients (46.0%) were infected with type 1a HCV strains, 52 (28.1%) with type 1b, 14 (7.6%) with type 2b, 13 (7.0%) with type 4, 5 (2.7%) with type 3a, 2 (1.1%) with type 2a, and 1 (0.5%) with type 2c. Thirteen HCV-positive patients (7.0%) could not be genotyped. The relatively low prevalence of genotype lb in this population of end-stage liver disease patients speaks against postulated higher pathogenicity of this genotype.
- Publication
Journal of Infectious Diseases, 1997, Vol 175, Issue 2, p448
- ISSN
0022-1899
- Publication type
Article