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- Title
Peru-15, an Improved Live Attenuated Oral Vaccine Candidate for Vibrio cholerae O1.
- Authors
Kenner, Julie R.; Coster, Trinka S.; Taylor, David N.; Trofa, Andrew F.; Barrera-Oro, Maria; Hyman, Tracy; Adams, Jennifer M.; Beattie, David T.; Killeen, Kevin P.; Spriggs, Dale R.; Mekalanos, John J.; Sadoff, Jerald C.
- Abstract
Cholera vaccine candidate Peru-15 was derived from a Vibrio cholerae O1 E1 Tor Inaba strain by deleting the cholera toxin genetic element, introducing the gene encoding cholera toxin B subunit into recA, and screening for nonmotility. In a controlled study, Peru-15 (2 × 108 cfu) was administered to 11volunteers. No vaccinee developed diarrhea, and 10 of 11 had >4-fold rises in vibriocidal antibody titers. One month later, 5 vaccinees and 5 control volunteers were challenged with wild type V. cholerae O1. Four of 5 controls developed diarrhea (mean, 1.9 L). Two Peru-15 vaccinees developed diarrhea, 1 with <0.3 L and 1 with ∼1.0 L; this latter volunteer had not developed a significant vibriocidalimmune response to vaccination. Peru-15 shows promise as a single-dose, oral cholera vaccine that is safe, immunogenic, and protective.
- Publication
Journal of Infectious Diseases, 1995, Vol 172, Issue 4, p1126
- ISSN
0022-1899
- Publication type
Article