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- Title
UMG1/CD3ε‐bispecific T‐cell engager redirects T‐cell cytotoxicity against diffuse large B‐cell lymphoma.
- Authors
Caracciolo, Daniele; Polerà, Nicoletta; Belmonte, Beatrice; Conforti, Francesco; Signorelli, Stefania; Gulino, Alessandro; Staropoli, Nicoletta; Tuccillo, Franca Maria; Bonelli, Patrizia; Juli, Giada; Grillone, Katia; Ascrizzi, Serena; Cirillo, Maria; Migale, Leonardo; Ballerini, Andrea; Pelizon, Cristina; Di Martino, Maria Teresa; Tagliaferri, Pierosandro; Riillo, Caterina; Tassone, Pierfrancesco
- Abstract
Summary: UMG1 is a unique epitope of CD43, not expressed by normal cells and tissues of haematopoietic and non‐haematopoietic origin, except thymocytes and a minority (<5%) of peripheral blood T lymphocytes. By immunohistochemistry analysis of tissue microarray and pathology slides, we found high UMG1 expression in 20%–24% of diffuse large B‐cell lymphomas (DLBCLs), including highly aggressive BCL2high and CD20low cases. UMG1 membrane expression was also found in DLBCL bone marrow‐infiltrating cells and established cell lines. Targeting UMG1 with a novel asymmetric UMG1/CD3ε‐bispecific T‐cell engager (BTCE) induced redirected cytotoxicity against DLBCL cells and was synergistic with lenalidomide. We conclude that UMG1/CD3ε‐BTCE is a promising therapeutic for DLBCLs.
- Subjects
DIFFUSE large B-cell lymphomas; CYTOTOXINS; T cells; BONE cells
- Publication
British Journal of Haematology, 2024, Vol 204, Issue 2, p555
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.19183