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- Title
In chronic lymphocytic leukaemia, SLAMF1 deregulation is associated with genomic complexity and independently predicts a worse outcome.
- Authors
Rigolin, Gian Matteo; Saccenti, Elena; Melandri, Aurora; Cavallari, Maurizio; Urso, Antonio; Rotondo, Francesco; Betulla, Anita; Tognolo, Lucia; Bardi, Maria Antonella; Rossini, Marika; Tammiso, Elisa; Bassi, Christian; Cavazzini, Francesco; Negrini, Massimo; Cuneo, Antonio
- Abstract
Summary: In a series of 349 patients with chronic lymphocytic leukaemia (CLL), we found lower levels of signalling lymphocytic activation molecule family member 1 (SLAMF1) expression in cases with highly complex karyotypes, as defined by the presence of five or more chromosomal abnormalities (CK5; P < 0·001) and with major chromosomal structural abnormalities (P < 0·001). SLAMF1 downregulation was significantly associated with advanced Binet Stage (P = 0·001), CD38 positivity (P < 0·001), high β2‐microglobulin levels (P < 0·001), immunoglobulin heavy chain variable region gene (IGHV) unmutated status (P < 0·001), 11q deletion (P < 0·001), tumour protein p53 (TP53) disruption (P = 0·011) and higher risk CLL International Prognostic Index categories (P < 0·001). Multivariate analysis showed that downregulated SLAMF1 levels had independent negative prognostic impact on time‐to‐first treatment (P < 0·001) and overall survival (P < 0·001).
- Subjects
CHRONIC leukemia; LYMPHOCYTIC leukemia; IMMUNOGLOBULIN heavy chains; P53 protein
- Publication
British Journal of Haematology, 2021, Vol 192, Issue 6, p1068
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.16865