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- Title
Multi-centre validation of the prognostic value of the haematopoietic cell transplantation- specific comorbidity index among recipient of allogeneic haematopoietic cell transplantation.
- Authors
ElSawy, Mahmoud; Storer, Barry E.; Pulsipher, Michael A.; Maziarz, Richard T.; Bhatia, Smita; Maris, Michael B.; Syrjala, Karen L.; Martin, Paul J.; Maloney, David G.; Sandmaier, Brenda M.; Storb, Rainer; Sorror, Mohamed L.
- Abstract
The haematopoietic cell transplantation-specific comorbidity index ( HCT- CI) was developed in a single centre as a weighted scoring system to predict risks of non-relapse mortality ( NRM) following allogeneic haematopoietic cell transplantation. Information on the performance of the HCT- CI in multi-centre studies is lacking in the literature. To that end, a collaborative multicentre retrospective study was initiated. Comorbidity data from 2523 consecutive recipients of human leucocyte antigen-matched grafts from five different US institutions were analysed. Among all patients, HCT- CI scores of 0 vs. 1-2 vs. ≥3 were associated with 2-year NRM rates of 14%, 23% and 39% ( P < 0·0001), respectively, and 2-year overall survival ( OS) rates of 74%, 61% and 39%, respectively ( P < 0·0001). Using regression models, increasing HCT- CI scores were independently associated with increases in hazard ratios for NRM and worse survival within individual institutions. The HCT- CI retained independent capacity for association with outcomes within different age as well as conditioning intensity groups. C-statistic estimates for the prognostic power of the HCT- CI for NRM and OS were 0·66 and 0·64, respectively. The estimates within each institution were overall similar. The HCT- CI is a valid tool for capturing comorbidities and predicting mortality after haematopoietic cell transplantation across different institutions.
- Subjects
HEMATOPOIETIC stem cell transplantation; COMORBIDITY; HOMOGRAFTS; SURGICAL complications; ANTIGENS
- Publication
British Journal of Haematology, 2015, Vol 170, Issue 4, p574
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.13476