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- Title
Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus.
- Authors
Schneider, Stephen H.; Khachadurian, Avedis K.; Amorosa, Louis F.; Clemow, Lynn; Ruderman, Neil B.; Schneider, S H; Khachadurian, A K; Amorosa, L F; Clemow, L; Ruderman, N B
- Abstract
Exercise is frequently recommended in the treatment of diabetes mellitus. Nevertheless, its use has been limited in clinical practice, and concerns about safety and efficacy persist. We have reviewed a 10-yr experience with 255 patients enrolled in a comprehensive diabetes program that emphasized physical training. A low maximal oxygen uptake (VO2max) was found in patients with non-insulin-dependent diabetes mellitus compared with sedentary control subjects. This was not accounted for by autonomic neuropathy and is unlikely to be due to subtle differences in life-style. Exercise-related proteinuria was common and occurred in 29% of patients and was associated with higher blood pressure levels at rest and during exercise, impaired VO2max, and decreased R-R interval variation. Regular exercise was associated with a modest decrease in resting and exercise blood pressure. Glycosylated hemoglobin levels and plasma triglycerides improved only in patients with non-insulin-dependent diabetes mellitus. Insulin requirements were significantly reduced in patients with insulin-dependent diabetes mellitus. Compliance for up to 3 mo in the program was acceptable but longer-term compliance was poor. Serious complications during the program were rare. Our experience suggests a program of regular aerobic training can be safely and effectively used in an outpatient population with diabetes mellitus for up to 3 mo.
- Subjects
TREATMENT of diabetes; TYPE 2 diabetes treatment; AGE distribution; BLOOD pressure; BLOOD sugar; CHOLESTEROL; COMPARATIVE studies; DIABETES; EXERCISE; HEART beat; TYPE 1 diabetes; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; TYPE 2 diabetes; PATIENT compliance; PROTEINURIA; RESEARCH; RESEARCH funding; TRIGLYCERIDES; EVALUATION research; LIFESTYLES; OXYGEN consumption
- Publication
Diabetes Care, 1992, Vol 15, Issue 11, p1800
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.15.11.1800