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- Title
Increased plasma endothelin in NIDDM patients with retinopathy.
- Authors
Kawamura, Makiko; Ohgawara, Hisako; Naruse, Mitsuhide; Suzuki, Nobuhiro; Iwasaki, Naoko; Naruse, Kiyoko; Hori, Sadao; Demura, Hiroshi; Omori, Yasue; Kawamura, M; Ohgawara, H; Naruse, M; Suzuki, N; Iwasaki, N; Naruse, K; Hori, S; Demura, H; Omori, Y
- Abstract
<bold>Objective: </bold>To elucidate the significance of ET in diabetic microvascular disease.<bold>Research Design and Methods: </bold>We determined plasma levels of ir-ET-1 in 25 NIDDM patients without hypertension and/or renal dysfunction.<bold>Results: </bold>The plasma levels of ir-ET-1 in NIDDM patients with simple (n = 8) and proliferative (n = 8) retinopathy were 0.58 +/- 0.04 pM and 0.60 +/- 0.04 pM, respectively, which were significantly higher than those in normal, nondiabetic subjects (0.24 +/- 0.02 pM [n = 31]) and NIDDM patients without retinopathy (0.30 +/- 0.05 pM [n = 9]).<bold>Conclusions: </bold>These results suggest that plasma ET-1 is related to diabetic microvascular disease.
- Publication
Diabetes Care, 1992, Vol 15, Issue 10, p1396
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.15.10.1396