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- Title
Effects of β3-adrenoceptor agonist on acute urinary retention in a rat model.
- Authors
Noh, Tae Il; Shim, Ji Sung; Kang, Sung Gu; Kang, Seok Ho; Cheon, Jun; Lee, Jeong Gu
- Abstract
Purpose: To investigate the protective effect of mirabegron on bladder dysfunction in an acute urinary retention rat model. Materials and methods: Thirty-six 16-week Sprague–Dawley rats were assigned to the mirabegron and normal saline (N/S) groups. Each group of eighteen was divided into sub-groups of 6 for 30 min, 2 h, and 24 h. They were administered mirabegron (10 mg/kg) and N/S daily for 4 weeks, respectively. Mirabegron and N/S groups were divided into sub-groups of 6 rats for 30 min, 2 h, and 24 h. The changes in bladder blood flow were measured using laser Doppler (moorVMS-LDF2). Histopathological examination of the bladder and nitric oxide (NO) measurement were performed. Result: During the urinary retention phase in the mirabegron group, it showed higher and rapider recovery of blood flow; the lowest at 19.5% ± 3.68% at 3 min, a significant recovery from the lowest value as 23.7 ± 3.4% at 10 min, than that in the N/S group; 15.1 ± 1.84% at 5 min, 23.7 ± 3.4% at 20 min, respectively (P < 0.05). At 30 min, 120 min, and 24 h after reperfusion, the recovery of blood flow in the mirabegron group was significantly higher than that in the N/S group (mirabegron: 41.1 ± 1.7%, 59.9 ± 7.2%, and 89.7 ± 4.4%, N/S: 31.3 ± 2.1%, 47.3 ± 4.5%, 83.9 ± 3.6%, respectively (P < 0.05)). NO levels tended to be higher in the mirabegron group; however, the difference was not statistically significant. Histological examination revealed that the mirabegron group showed recovery close to normal tissue after 24 h. Conclusions: In an acute urinary retention rat model, mirabegron maintained and restored higher bladder blood flow, resulting in protective and recovery effect after acute urinary retention.
- Subjects
ANIMAL disease models; RETENTION of urine; SPRAGUE Dawley rats; BLOOD flow; RATS
- Publication
World Journal of Urology, 2021, Vol 39, Issue 12, p4427
- ISSN
0724-4983
- Publication type
Article
- DOI
10.1007/s00345-021-03774-7