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- Title
Isolation, Characterization, Bioassay and X-ray Crystallographic Study of Phytoconstituents from Bixa orellana Leaves.
- Authors
Parveen, Mehtab; Malla, Ali; Ali, Akhtar; Nami, Shahab; Silva, P.; Silva, Manuela
- Abstract
A new ellagic acid derivative, 3-O-methyl ellagic acid dihydrate ( 4), along with three known phytoconstituents, 4-acetylresorcinol ( 1), 4-hydroxyphenylmethyl ketone ( 2), and docosanoic acid docosyl ester ( 3), were isolated from the leaves of Bixa orellana L. for the first time. Their structures were elucidated on the basis of chemical and physical data (IR, UV, H NMR, C NMR, and mass). Herein, we report the extraction, isolation, characterization, and biological activities of phytoconstituents isolated from the leaves of Bixa orellana. The structure of compound 4 was further confirmed by X-ray crystallographic studies. The isolated compounds 1-4 were screened for their antimicrobial activity by the disc diffusion method using ciprofloxacin and amphotericin B as standard drugs. Moreover, compound 4 was evaluated for its plausible anticancer activity using MTT assay.
- Subjects
ELLAGIC acid; ANTIOXIDANTS; X-ray reflection; X-Ray expertising; IONIZING radiation
- Publication
Chemistry of Natural Compounds, 2015, Vol 51, Issue 1, p62
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-015-1204-0