We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Diterpenoid compounds from Vitex agnus-castus.
- Authors
Pal, Mahesh; Li, Sheng-Hong; Tewari, Shri; Sun, Han-Dong
- Abstract
A new diterpenoid alkaloid having an α,β-unsaturated γ-lactam moiety, 9α-hydroxy-13(14)-labden-16,15-amide ( 1), together with five known ones, was isolated from the fruits of Vitex angus-castus. The structure of 1 was elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques.The cytotoxicity of each compound was evaluated against human chronic myelogenous leukemia (K562) cell lines. Compound 1 was found to be the most potent with IC value of 0.70 μg/mL.
- Subjects
DITERPENES; VITEX agnus-castus; SPECTROMETRY; MYELOID leukemia; CELL lines
- Publication
Chemistry of Natural Compounds, 2013, Vol 49, Issue 4, p635
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-013-0697-7