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- Title
Efficient synthesis of N′-benzylidene-2-hydroxymethylbenzohydrazides from the one-pot reaction of phthalide, hydrazine and aldehydes.
- Authors
Alifu, Zulipiye; Nizhamu, Maijidan; Ablajan, Keyume
- Abstract
We report an efficient, catalyst-free, one-pot synthesis of (E)-N′-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives by the one-pot reaction of phthalide, hydrazine hydrate and aldehyde. Advantages of this synthetic approach include mild reaction conditions and environmentally friendly nature, and the ability to provide a wide range of desired compounds in moderate to excellent yields. Here we introduce a green and efficient one-pot three-component protocol for the synthesis of (E)-N′-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives in ethanol without any catalyst.
- Subjects
ALDEHYDES; HYDRAZINE; HYDRAZINE derivatives; PHTHALAZINE; AROMATIC aldehydes; ETHANOL; CATALYSTS
- Publication
Research on Chemical Intermediates, 2019, Vol 45, Issue 10, p4779
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-019-03863-8