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- Title
Dnajb8, a target gene of SOX30, is dispensable for male fertility in mice.
- Authors
Fengsong Wang; Shuai Kong; Xuechun Hu; Xin Li; Bo Xu; Qiuling Yue; Kaiqiang Fu; Lan Ye; Shun Bai
- Abstract
Background. The DNAJ family of molecular chaperones maintains protein homeostasis in mitotic and postmeiotic cells, especially germ cells. Recently, we found that the transcription factor SOX30 initiates transcription of Dnajb8 during late meiosis and spermiogenesis in mouse testes. Methods. We used the CRISPR/Cas9 system to generate Dnajb8 mutant mice and analyze the phenotype of the Dnajb8 mutants. Results. Although Dnajb8 is an evolutionarily conserved gene, it is not essential for spermatogenesis and male fertility. We provide this phenotypic information, which could prevent duplicative work by other groups.
- Subjects
FERTILITY; MOLECULAR chaperones; SPERMATOGENESIS; GERM cells; TRANSCRIPTION factors; MICE
- Publication
PeerJ, 2020, p1
- ISSN
2167-8359
- Publication type
Article
- DOI
10.7717/peerj.10582