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- Title
Synthesis and Crystal Structure of 1-(3-Amino-4-Morpholino-1H-Indazole-1-Carbonyl)-N-(4-Methoxyphenyl)Cyclopropane-1-Carboxamide, a Molecule with Antiproliferative Activity.
- Authors
Lu, J. F.; Zhao, J.; Sun, Ming; Ji, X. H.; Huang, Pei; Ge, H. G.
- Abstract
Compound 1-(3-amino-4-morpholino-1H-indazole-1-carbonyl)-N-(4-methoxyphenyl)cyclopropane-1-carboxamide (C22H23N5O3, Mr = 870.96) was synthesized by condensation of 1-(4-methoxyphenylcarbamoyl)cyclopropane-1-carboxylic acid with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and subsequent cyclization with hydrazine hydrate. The crystal structure was determined. The results of biological activity determination indicated that the compound exhibited significant inhibitory activity against some cancer cell lines.
- Subjects
CRYSTAL structure; CELL lines; CANCER cells; MOLECULES; HYDRAZINE
- Publication
Crystallography Reports, 2021, Vol 66, Issue 3, p455
- ISSN
1063-7745
- Publication type
Article
- DOI
10.1134/S1063774521030160