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- Title
Role of Retama Raetam on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model.
- Authors
Menshawy, Medhat M.; Farrag, Abdel Razik H.; El Toumy, Sayed A.; Muhamed, Gamila S.
- Abstract
The methanol extract of the seeds of Retama raetam was studied for its preventive and curative effects in gentamicin-induced acute renal failure in rats. Thirty rats were divided into five different groups; each group contains six rats. Group I was served as a control group, Group II, III and IV were administered a daily dose of gentamicin (40 mg/kg body weight s.c) for 13 days. In case of group III, rats were administered with the extract at a dose of 30 mg/kg body weight on the 14th day onwards for 10 days. While, in group IV rats were treated with an oral dose of the extract equivalent to 30 mg/kg b.w. before 2hs of subcutaneous injection of gentamicin for 13 days. Group V rats were given the extract at a dose of 30 mg/kg body weight for 13 days. Serum urea and creatinine levels were measured. Moreover, histopathological as well as morphometrical investigations were performed. In the gentamicin model, the methanol extract of R. raetam (30 mg/kg b. wt.) reduced blood urea and serum creatinine effectively in the curative and the preventive treatment. Light microscopic examination of the renal tissues from gentamicin-treated rats revealed severe histopathological and morphometrical changes, whereas specimens obtained from extract-treated rats revealed only mild changes. These findings recommend that the methanol extract of the seeds of R. raetam counteract the deleterious effect of gentamicin on renal tubular function and structure.
- Subjects
PARKINSONIA aculeata; GENTAMICIN; ACUTE kidney failure
- Publication
Egyptian Academic Journal of Biological Sciences. D, Histology & Histochemistry, 2021, Vol 13, Issue 2, p35
- ISSN
2090-0775
- Publication type
Article
- DOI
10.21608/EAJBSD.2021.186478