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- Title
Succinamide Derivatives Ameliorate Neuroinflammation and Oxidative Stress in Scopolamine-Induced Neurodegeneration.
- Authors
Iqbal, Sumbal; Shah, Fawad Ali; Naeem, Komal; Nadeem, Humaira; Sarwar, Sadia; Ashraf, Zaman; Imran, Muhammad; Khan, Tariq; Anwar, Tayyaba; Li, Shupeng
- Abstract
Oxidative stress-mediated neuroinflammatory events are the hallmark of neurodegenerative diseases. The current study aimed to synthesize a series of novel succinamide derivatives and to further investigate the neuroprotective potential of these compounds against scopolamine-induced neuronal injury by in silico, morphological, and biochemical approaches. The characterization of all the succinamide derivatives was carried out spectroscopically via proton NMR (1H-NMR), FTIR and elemental analysis. Further in vivo experiments showed that scopolamine induced neuronal injury, characterized by downregulated glutathione (GSH), glutathione S-transferase (GST), catalase, and upregulated lipid peroxidation (LPO). Moreover, scopolamine increased the expression of inflammatory mediators such as cyclooxygenase2 (COX2), nuclear factor kappa B (NF-kB), tumor necrosis factor (TNF-α), further associated with cognitive impairment. On the other hand, treatment with succinamide derivatives ameliorated the biochemical and immunohistochemical alterations induced by scopolamine, further supported by the results obtained from molecular docking and binding affinities.
- Subjects
TROPANES; NF-kappa B; INFLAMMATION; INFLAMMATORY mediators; OXIDATIVE stress; TUMOR necrosis factors; LIPID peroxidation (Biology); MOLECULAR docking
- Publication
Biomolecules (2218-273X), 2020, Vol 10, Issue 3, p443
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom10030443