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- Title
Nonmotor Symptoms in a Malaysian Parkinson's Disease Population.
- Authors
Shahrul Azmin; Abdul Manaf Khairul Anuar; Hui Jan Tan; Wan Yahya Nafisah; Azman Ali Raymond; Othman Hanita; Shamsul Azhar Shah; Mohamed Ibrahim Norlinah
- Abstract
Background.The nonmotor symptoms are important determinants of health and quality of life in Parkinson's disease but are notwell recognized and addressed in clinical practice.This study was conducted to determine the prevalence of nonmotor symptoms and their impact on quality of life in patients with Parkinson's disease. Methods.This was a cross-sectional study among patients with idiopathic Parkinson's disease. Exclusion criteria were a Mini Mental State Examination score of <21/30. Prevalence of nonmotor symptoms was determined using the NMSQuest.The severity of nonmotor symptoms and the quality of life were assessed using validated disease-specific questionnaires (PDQ-39 and NMSS). Results. A total of 113 patients consisting of 60 males and 53 females were recruited.Themedian duration of illness was 5.0 (2.0-8.0) years.Theprevalence rate of nonmotor symptoms in our cohortwas 97.3%. The most common reported nonmotor symptom in our cohort was gastrointestinal (76.1%). We found that the severity of the nonmotor symptoms was associated with poorer quality of life scores (rs : 0.727, P < 0.001). Conclusions. Nonmotor symptoms were highly prevalent in our patients with Parkinson's disease and adversely affected the quality of life of our patients. In contrast to western studies, the most common nonmotor symptom is gastrointestinal.The possibility of an Asian diet playing a role in this observation requires further study.
- Subjects
MALAYSIA; ACADEMIC medical centers; GASTROINTESTINAL system; PARKINSON'S disease; PSYCHOLOGICAL tests; QUALITY of life; QUESTIONNAIRES; STATISTICS; DATA analysis; DISEASE prevalence; CROSS-sectional method; SEVERITY of illness index; SYMPTOMS
- Publication
Parkinson's Disease (20420080), 2014, p1
- ISSN
2090-8083
- Publication type
Article
- DOI
10.1155/2014/472157