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- Title
Analysis of HLA Antigens in Croatian Patients with Psoriasis.
- Authors
Kastelan, Marija; Gruber, Franjo; Cecuk, Esma; Kerhin-Brkljacić, Vesna; Brkljacić-Surkalović, Ljerka; Kastelan, Andrija
- Abstract
In common with most autoimmune diseases, psoriasis is associated with some HLA antigens. We studied the distribution of HLA antigens in Croatian patients with psoriasis: 108 patients were divided into groups according to family history and age of disease onset. HLA antigens were analyzed serologically and HLA-C alleles were analyzed using polymerase chain reaction. We found significant increases in HLA-A2, -B17, -B37 and-B13 antigens and highly significant increases in HLA-Cw*0602 and DR7 antigens in psoriatic patients compared with controls. Patients with type I psoriasis (early onset, positive family history) showed highly significant associations with Cw*0602 [p< 0.00001; relative risk (RR) = 14.45] and DR7 (p< 0.00001; RR = 15.09) antigens. Patients with type II psoriasis (late onset, no family history) had a significant association with Cw*03 antigen (p= 0.008; RR = 0.17). In conclusion, HLA-B13, -B17, Cw*0602 and-DR7 antigens are associated with a significant risk of psoriasis in the Croatian population and the Cw*0602 allele has the strongest association, especially for type I psoriasis.
- Subjects
CROATIA; RIJEKA (Croatia); HLA histocompatibility antigens; PSORIASIS; POLYMERASE chain reaction
- Publication
Acta Dermato-Venereologica, 2000, Vol 80, p12
- ISSN
0001-5555
- Publication type
Article
- DOI
10.1080/00015550050500040