We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Severe hemoperitoneum resulting from restart of letrozole after oocyte retrieval procedure: a case report.
- Authors
Huang, Haipeng; Takai, Yasushi; Samejima, Kouki; Gomi, Yosuke; Narita, Tatsuya; Ichinose, Shunichiro; Itaya, Yukiko; Ono, Yosihisa; Matsunaga, Sigetaka; Saitoh, Masahiro; Seki, Hiroyuki
- Abstract
<bold>Background: </bold>In the field of oncofertility, patients with breast cancer are often administered letrozole as an adjuvant drug before and after oocyte retrieval to prevent an increase in circulating estradiol.<bold>Case Presentation: </bold>We report a case of abdominal hemorrhage due to an ovarian rupture in a 29-year-old Japanese patient who restarted letrozole 2 days after an oocyte retrieval procedure in which 14 mature oocytes were retrieved. The patient had sought embryo cryopreservation as a fertility preservation option before undergoing treatment for recurrent breast cancer. A day after restarting letrozole treatment, the patient unexpectedly developed severe abdominal pain. Laparoscopic hemostasis was performed to manage the ovarian swelling and hemorrhage.<bold>Conclusions: </bold>The ovaries can be restimulated by restart letrozole after an oocyte retrieval procedure. Therefore, reproductive-medicine practitioners should understand the potential complications of letrozole administration in such cases and take steps to ensure that they are minimized.
- Subjects
OVUM; LETROZOLE; BREAST cancer; FERTILITY preservation; ABDOMINAL pain; OOCYTE retrieval; DIGESTIVE system diseases; CANCER relapse; HUMAN reproductive technology; INDUCED ovulation; BREAST tumors; HEMORRHAGE
- Publication
Journal of Medical Case Reports, 2021, Vol 15, Issue 1, p1
- ISSN
1752-1947
- Publication type
journal article
- DOI
10.1186/s13256-021-02938-8