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- Title
Longitudinal Feasibility of the Montreal Cognitive Assessment (MoCA) in Non-Demented ALS Patients.
- Authors
Aiello, Edoardo Nicolò; Solca, Federica; Torre, Silvia; Colombo, Eleonora; Maranzano, Alessio; De Lorenzo, Alberto; Patisso, Valerio; Treddenti, Mauro; Curti, Beatrice; Morelli, Claudia; Doretti, Alberto; Verde, Federico; Ferrucci, Roberta; Barbieri, Sergio; Ruggiero, Fabiana; Priori, Alberto; Silani, Vincenzo; Ticozzi, Nicola; Poletti, Barbara
- Abstract
Introduction: The present study aimed at testing the longitudinal feasibility of the Montreal Cognitive Assessment (MoCA) in an Italian cohort of non-demented amyotrophic lateral sclerosis (ALS) patients. Methods:N = 39 non-demented ALS patients were followed-up at a 5-to-10-month interval (M = 6.8; SD = 1.4) with the MoCA and the Edinburgh Cognitive and Behavioral ALS Screen (ECAS). Practice effects, test-retest reliability, and predictive validity (against follow-up ECAS scores) were assessed. Reliable change indices (RCIs) were derived via a regression-based approach by accounting for retest interval and baseline confounders (i.e., demographics, disease duration, and severity and progression rate). Results: At retest, 100% and 69.2% of patients completed the ECAS and the MoCA, respectively. Patients who could not complete the MoCA showed a slightly more severe and fast-progressing disease. The MoCA was not subject to practice effects (t[32] = −0.80; p = 0.429) and was reliable at retest (intra-class correlation = 0.82). Moreover, baseline MoCA scores predicted the ECAS at retest. RCIs were successfully derived – with baseline MoCA scores being the only significant predictor of retest performances (ps < 0.001). Conclusions: As long as motor disabilities do not undermine its applicability, the MoCA appears to be longitudinally feasible at a 5-to-10-month interval in non-demented ALS patients. However, ALS-specific screeners – such as the ECAS – should be preferred whenever possible.
- Subjects
MONTREAL Cognitive Assessment; AMYOTROPHIC lateral sclerosis; INTRACLASS correlation; PREDICTIVE validity; STATISTICAL reliability
- Publication
European Neurology, 2024, Vol 87, Issue 2, p79
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000538828