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- Title
The β fiβrinogen gene G-455A polymorphism in Asian suβjects with coronary heart disease: A meta analysis.
- Authors
Fajar, Jonny Karunia
- Abstract
Background: There are many studies about the association of b fibrinogen gene G-455A polymorphism and the risk of coronary heart disease (CHD). However, the results of these studies are inconsistent. Objective: This study aimed to investigate the association of b fibrinogen gene G-455A polymorphism with the risk of CHD using meta analysis. This study was limited to the Asian population. Methods: Published studies from PubMed, Embase, and CNKI databases (up to December 20th, 2015) were searched for eligible publications. The following information was extracted from each study: (1) name of first author; (2) year of publication; (3) country of origin; (4) sample size of cases and controls, and (5) size of each allele. The combined odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between b fibrinogen gene G-455A polymorphism and the risk of CHD were assessed using random or fixed effect model. A comprehensive meta analysis (CMA) 2.0 was used to analyze the data. Results: Nineteen studies (4011 cases/3673 controls) regarding the association of b fibrinogen gene G-455A polymorphism and the risk of CHD were included in this meta analysis. The results indicated that b fibrinogen gene G-455A polymorphism was associated with increased (A vs. G: OR 95% CI= 1.42 [1.19-1.70], p<0.001; AA vs. GG +GA: OR 95% CI= 1.60 [1.13-2.26], p= 0.008; GA vs. GG + AA: OR 95% CI = 1.30 [1.07-1.58], p= 0.008) and decreased the risk of CHD (G vs. A: OR 95% CI= 0.70 [0.59-0.84], p <0.001; GG vs. GA +AA: OR 95% CI= 0.68 [0.55-0.84], p< 0.001). Conclusions: In the Asian population, the b fibrinogen gene G-455A polymorphism was associated with the risk of CHD.
- Subjects
FIBRINOGEN; GENETIC polymorphisms; CORONARY disease; META-analysis; CARDIOVASCULAR diseases
- Publication
Egyptian Journal of Medical Human Genetics, 2017, Vol 18, Issue 1, p19
- ISSN
1110-8630
- Publication type
Article
- DOI
10.1016/j.ejmhg.2016.06.002