We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Lymphoplasmacytic lymphoma associated with diffuse large B-cell lymphoma: Progression or divergent evolution?
- Authors
Boiza-Sánchez, Macarena; Manso, Rebeca; Balagué, Olga; Chamizo, Cristina; Askari, Elham; Salgado, Rocío Nieves; Blas-López, Carlos; Aguirregoicoa-García, Elena; Menárguez, Javier; Santonja, Carlos; Adrados, Magdalena; Limeres-González, Miguel Ángel; Piris, Miguel Ángel; Rodríguez-Pinilla, Socorro María
- Abstract
Aim: Lymphoplasmacytic lymphoma (LPL) is an indolent mature B-cell-neoplasm with involvement of the bone marrow. At least 90% of LPLs carry MYD88-L265P mutation and some of them (~10%) transform into diffuse large B-cell-lymphoma (DLBCL). Material and methods: Over the past 15 years we have collected 7 cases where the both LPL and DLBCL were diagnosed in the same patient. Clinical records, analytical data and histopathological specimens were reviewed. FISH studies on paraffin-embedded tissue for MYC, BCL2 and BCL6 genes were performed, as well as MYD88-L265P mutation and IGH rearrangement analysis by PCR. A mutational study was done by massive next generation sequencing (NGS). Results: There were 4 women and 3 men between 36–91 years of age. Diagnoses were made simultaneously in 4 patients. In two cases the LPL appeared before the DLBCL and in the remaining case the high-grade component was discovered 5 years before the LPL. In 6 cases both samples shared the MYD88-L265P mutation. IGH rearrangement analysis showed overlapping features in two of 6 cases tested. Mutational study was evaluable in three cases for both samples showing shared and divergent mutations. Conclusions: These data suggest different mechanisms of DLBCL development in LPL patients.
- Subjects
WALDENSTROM'S macroglobulinemia; MEDICAL records; BONE marrow; LYMPHOMAS
- Publication
PLoS ONE, 2020, Vol 15, Issue 11, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0241634