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- Title
Bone Mineral Density and the Risk of Hip and Knee Osteoarthritis: The Johnston County Osteoarthritis Project.
- Authors
Barbour, Kamil E.; Murphy, Louise B.; Helmick, Charles G.; Hootman, Jennifer M.; Renner, Jordan B.; Jordan, Joanne M.
- Abstract
<bold>Objective: </bold>To address knowledge gaps regarding the relationship between bone mineral density (BMD) and incident hip or knee osteoarthritis (OA); specifically, lack of information regarding hip OA or symptomatic outcomes.<bold>Methods: </bold>Using data (n = 1,474) from the Johnston County Osteoarthritis Project's first (1999-2004) and second (2005-2010) followup of participants ages ≥45 years, we examined the association between total hip BMD and both hip and knee OA. Total hip BMD was measured using dual x-ray absorptiometry, and participants were classified into sex-specific quartiles (low, intermediate low, intermediate high, and high). Radiographic OA (ROA) was defined as development of Kellgren/Lawrence grade ≥2. Symptomatic ROA (sROA) was defined as onset of both ROA and symptoms. Weibull regression modeling was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs).<bold>Results: </bold>Median followup time was 6.5 years (range 4.0-10.2 years). In multivariate models, and compared with participants with low BMD, those with intermediate high and high BMD were less likely to develop hip sROA (HR 0.52 [95% CI 0.31-0.86] and 0.56 [95% CI 0.31-0.86], respectively; P = 0.024 for trend); high BMD was not associated (HR 0.69 [95% CI 0.45-1.06]) with risk of hip ROA. Compared with participants with low BMD, those with intermediate low and intermediate high total hip BMD were more likely to develop knee sROA (HR 2.15 [95% CI 1.40-3.30] and 1.65 [95% CI 1.02-2.67], respectively; P = 0.325 for trend); similar associations were seen with knee ROA.<bold>Conclusion: </bold>Our findings suggest that higher BMD may reduce the risk of hip sROA, while intermediate levels may increase the risk of both knee sROA and ROA.
- Subjects
NORTH Carolina; CHI-squared test; HIP joint; HIP joint diseases; KNEE diseases; MULTIVARIATE analysis; OSTEOARTHRITIS; PROBABILITY theory; RESEARCH funding; TIME; BONE density; DISEASE incidence; SEVERITY of illness index; PHOTON absorptiometry; PREVENTION
- Publication
Arthritis Care & Research, 2017, Vol 69, Issue 12, p1863
- ISSN
2151-464X
- Publication type
journal article
- DOI
10.1002/acr.23211