We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Renal calcium handling in familial hypocalciuric hypercalcemia.
- Authors
Watanabe, Hiroko; Sutton, Roger A. L.
- Abstract
We have determined calcium and sodium excretion rates in three members of a kinship with familial hypocalciuric hypercalcemia (FHH) and in four patients with primary hyperparathyroidism (PHP) under control conditions and following the intravenous administration of chlorotiazide or furosemide. The characteristic hypocalciuria of FHH, evidenced by a significantly reduced urinary calcium/creatinine ratio compared with that of PHP, is present under control conditions (0.08 vs. 0.26 mg calcium/rag creatinine, respectively, P < 0.05), and after chlorothiazide (0.14 vs. 0.53, respectively, P < 0.01). However, after furosemide infusion the calcium/creatinine ratio is no longer lower in FHH than in PHP (1.12 vs. 1.14, respectively, P > 0.05). These data suggest that, in FHH, tubular calcium reabsorption is enhanced in the thick ascending limb of Henle's loop, the site of action of furosemide. However, the data do not exclude the presence of an abnormality at a more distal site in the nephron.
- Subjects
HYPERCALCEMIA; CALCIUM metabolism disorders; CALCIUM; HYPERPARATHYROIDISM; FUROSEMIDE; DIURETICS; NEPHROLOGY
- Publication
Kidney International, 1983, Vol 24, Issue 3, p353
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1983.166