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Potential therapeutic applications of autophagy.
- Published in:
- 2007
- By:
- Publication type:
- journal article
Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity.
- Published in:
- Expert Reviews in Molecular Medicine, 2012, v. 14, p. 1, doi. 10.1017/erm.2012.10
- By:
- Publication type:
- Article
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29552-6
- By:
- Publication type:
- Article
Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30751-4
- By:
- Publication type:
- Article
Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3.
- Published in:
- 2016
- By:
- Publication type:
- journal article
High-Throughput Screen of Natural Product Extracts in A Yeast Model of Polyglutamine Proteotoxicity.
- Published in:
- Chemical Biology & Drug Design, 2014, v. 83, n. 4, p. 440, doi. 10.1111/cbdd.12259
- By:
- Publication type:
- Article
Expanding the Number of 'Druggable' Targets: Non-Enzymes and Protein-Protein Interactions.
- Published in:
- Chemical Biology & Drug Design, 2013, v. 81, n. 1, p. 22, doi. 10.1111/cbdd.12066
- By:
- Publication type:
- Article
Insight into Amyloid Structure Using Chemical Probes.
- Published in:
- Chemical Biology & Drug Design, 2011, v. 77, n. 6, p. 399, doi. 10.1111/j.1747-0285.2011.01110.x
- By:
- Publication type:
- Article
Intersecting PTMS regulate clearance of pathogenic tau by the CHIP ubiquitin ligase.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.062036
- By:
- Publication type:
- Article
Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC‐induced neurons with the V337M MAPT mutation.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.051471
- By:
- Publication type:
- Article
Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1063, doi. 10.3390/ijms23031063
- By:
- Publication type:
- Article
The YΦ motif defines the structure-activity relationships of human 20S proteasome activators.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28864-x
- By:
- Publication type:
- Article
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22501-9
- By:
- Publication type:
- Article
Structure–activity Relationships of Amyloid Beta-aggregation Inhibitors Based on Curcumin: Influence of Linker Length and Flexibility.
- Published in:
- Chemical Biology & Drug Design, 2007, v. 70, n. 3, p. 206, doi. 10.1111/j.1747-0285.2007.00557.x
- By:
- Publication type:
- Article
Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance.
- Published in:
- PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035566
- By:
- Publication type:
- Article
Clarifying allosteric control of flap conformations in the 1TW7 crystal structure of HIV-1 protease.
- Published in:
- Proteins, 2009, v. 74, n. 4, p. 872, doi. 10.1002/prot.22195
- By:
- Publication type:
- Article
Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
- Published in:
- 2019
- By:
- Publication type:
- Correction Notice
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11594-y
- By:
- Publication type:
- Article
Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07718-5
- By:
- Publication type:
- Article
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07012-4
- By:
- Publication type:
- Article
Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 39, p. 12079, doi. 10.1523/JNEUROSCI.3345-09.2009
- By:
- Publication type:
- Article
Quantifying Prefibrillar Amyloids in vitro by Using a 'Thioflavin-Like' Spectroscopic Method.
- Published in:
- ChemBioChem, 2010, v. 11, n. 13, p. 1889, doi. 10.1002/cbic.201000358
- By:
- Publication type:
- Article
Imbalance of Hsp70 family variants fosters tau accumulation.
- Published in:
- FASEB Journal, 2013, v. 27, n. 4, p. 1450, doi. 10.1096/fj.12-220889
- By:
- Publication type:
- Article
Identification of Key Hinge Residues Important for Nucleotide-Dependent Allostery in <i>E. coli</i> Hsp70/DnaK.
- Published in:
- PLoS Computational Biology, 2013, v. 9, n. 11, p. 1, doi. 10.1371/journal.pcbi.1003279
- By:
- Publication type:
- Article
Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.
- Published in:
- 2020
- By:
- Publication type:
- journal article
KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.
- Published in:
- Science Translational Medicine, 2018, v. 10, n. 454, p. 1, doi. 10.1126/scitranslmed.aar2718
- By:
- Publication type:
- Article
Synthetische multivalente Liganden als Sonden für die Signaltransduktion.
- Published in:
- Angewandte Chemie, 2006, v. 118, n. 15, p. 2408, doi. 10.1002/ange.200502794
- By:
- Publication type:
- Article
Inter-receptor communication through arrays of bacterial chemoreceptors.
- Published in:
- Nature, 2002, v. 415, n. 6867, p. 81, doi. 10.1038/415081a
- By:
- Publication type:
- Article
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.
- Published in:
- Human Molecular Genetics, 2015, v. 24, n. 14, p. 3971, doi. 10.1093/hmg/ddv135
- By:
- Publication type:
- Article
Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.
- Published in:
- Science Signaling, 2020, v. 13, n. 622, p. 1, doi. 10.1126/scisignal.aay1478
- By:
- Publication type:
- Article
A small molecule-directed approach to control protein localization and function.
- Published in:
- Yeast, 2008, v. 25, n. 8, p. 577, doi. 10.1002/yea.1610
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- Publication type:
- Article
Hsp70 molecular chaperones and Parkinson's disease.
- Published in:
- Biopolymers, 2010, v. 93, n. 3, p. 218, doi. 10.1002/bip.21302
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- Publication type:
- Article
Special series: Molecular chaperones in protein folding and disease.
- Published in:
- Biopolymers, 2010, v. 93, n. 3, p. 209, doi. 10.1002/bip.21290
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- Publication type:
- Article
Structure and function of the molecular chaperone Hsp104 from yeast.
- Published in:
- Biopolymers, 2010, v. 93, n. 3, p. 252, doi. 10.1002/bip.21301
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- Publication type:
- Article
Interplay between protein homeostasis networks in protein aggregation and proteotoxicity.
- Published in:
- Biopolymers, 2010, v. 93, n. 3, p. 229, doi. 10.1002/bip.21304
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- Publication type:
- Article
Hsp90 and co-chaperones twist the functions of diverse client proteins.
- Published in:
- Biopolymers, 2010, v. 93, n. 3, p. 211, doi. 10.1002/bip.21292
- By:
- Publication type:
- Article
Identifying protein stabilizing ligands using GroEL.
- Published in:
- Biopolymers, 2010, v. 93, n. 3, p. 237, doi. 10.1002/bip.21319
- By:
- Publication type:
- Article
A poke in the eye: Inhibiting HIV-1 protease through its flap-recognition pocket.
- Published in:
- Biopolymers, 2008, v. 89, n. 8, p. 643, doi. 10.1002/bip.20993
- By:
- Publication type:
- Article
Synthetic Multivalent Ligands as Probes of Signal Transduction.
- Published in:
- Angewandte Chemie International Edition, 2006, v. 45, n. 15, p. 2348, doi. 10.1002/anie.200502794
- By:
- Publication type:
- Article
Visualization of Single Multivalent Receptor-Ligand Complexes by Transmission Electron Microscopy.
- Published in:
- Angewandte Chemie International Edition, 2000, v. 39, n. 24, p. 4567, doi. 10.1002/1521-3773(20001215)39:24<4567::AID-ANIE4567>3.0.CO;2-F
- By:
- Publication type:
- Article
A model in which heat shock protein 90 targets protein-folding clefts: Rationale for a new approach to neuroprotective treatment of protein folding diseases.
- Published in:
- Experimental Biology & Medicine, 2014, v. 239, n. 11, p. 1405, doi. 10.1177/1535370214539444
- By:
- Publication type:
- Article
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.
- Published in:
- Molecular Neurodegeneration, 2010, v. 5, p. 45, doi. 10.1186/1750-1326-5-45
- By:
- Publication type:
- Article
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
- Published in:
- Journal of Neuroscience, 2018, v. 38, n. 15, p. 3680, doi. 10.1523/JNEUROSCI.2369-17.2018
- By:
- Publication type:
- Article
Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.
- Published in:
- Journal of Neuroinflammation, 2014, v. 11, n. 1, p. 1, doi. 10.1186/s12974-014-0152-0
- By:
- Publication type:
- Article
Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.
- Published in:
- 2014
- By:
- Publication type:
- journal article
Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52075-1
- By:
- Publication type:
- Article
Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50459-x
- By:
- Publication type:
- Article
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48569-7
- By:
- Publication type:
- Article
A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats.
- Published in:
- Frontiers in Neuroscience, 2024, p. 1, doi. 10.3389/fnins.2024.1263724
- By:
- Publication type:
- Article
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.
- Published in:
- Nature Chemical Biology, 2013, v. 9, n. 2, p. 112, doi. 10.1038/nchembio.1140
- By:
- Publication type:
- Article