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- Title
TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: Limitations of anti-TNF therapy for degenerative disc disease.
- Authors
Papuga, M. Owen; Kwok, Edmund; You, Zhigang; Rubery, Paul T.; Dougherty, Paul E.; Pryhuber, Gloria; Beck, Christopher A.; Hilton, Matthew J.; Awad, Hani A.; Schwarz, Edward M.
- Abstract
The article presents a study that examines the relationship between chronic compression and tumor necrosis factor (TNF) signaling in compression-induced bone marrow edema (BME). The study also examines the effectiveness of anti-TNF therapy. An overview of the nature, incidence and examination of lower back pain (LBP) as well as the specific ankylosing spondylitis (ASp) are provided. The association of BME with chronic LBP is explained. Results show that TNF prompts induction of BME and that anti-TNF therapy does not benefit chronic BME signals.
- Subjects
BONE marrow diseases; EDEMA; TUMOR necrosis factors; BACKACHE; ANKYLOSING spondylitis
- Publication
Journal of Orthopaedic Research, 2011, Vol 29, Issue 9, p1367
- ISSN
0736-0266
- Publication type
Article
- DOI
10.1002/jor.21370