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- Title
Provocation of microvessel spasm by low-dose acetylcholine in patients with suspected coronary artery disease: two case reports.
- Authors
Masaki N; Takase B; Satomura K; Akima T; Matsushima Y; Hosaka H; Hamabe A; Kurita A; Ohsuzu F
- Abstract
Endothelial dysfunction plays an important role in the pathogenesis of cardiac syndrome X, and intracoronary low-dose acetylcholine infusion is a widely used diagnostic modality for studying the coronary artery endothelial function. The authors herein report 2 cases of cardiac syndrome X with coronary artery endothelial dysfunction and microvessel spasm. The findings of non-invasive testing were positive for ischemia. Coronary angiograms appeared entirely normal in both cases. However, the intracoronary infusion of low-dose (1.5-15 microg/minute) acetylcholine demonstrated an impairment of the coronary blood flow response and consequently provoked an ST-segment elevation in an electrocardiogram. The coronary angiograms showed no spasm in the epicardial arteries. These patients are thus suggested to have cardiac syndrome X with microvessel spasms associated with coronary artery endothelial dysfunction.
- Publication
Angiology, 2005, Vol 56, Issue 2, p211
- ISSN
0003-3197
- Publication type
Journal Article
- DOI
10.1177/000331970505600211