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- Title
Lower diastolic wall strain is associated with coronary revascularization in patients with stable angina.
- Authors
Jaehuk Choi; Min-Kyung Kang; Chaehoon Han; Sang Muk Hwang; Sung Gu Jung; Han-Kyul Kim; Kwang Jin Chun; Seonghoon Choi; Jung Rae Cho; Namho Lee; Choi, Jaehuk; Kang, Min-Kyung; Han, Chaehoon; Hwang, Sang Muk; Jung, Sung Gu; Kim, Han-Kyul; Chun, Kwang Jin; Choi, Seonghoon; Cho, Jung Rae; Lee, Namho
- Abstract
<bold>Background: </bold>Left ventricular (LV) diastolic dysfunction occurs earlier in the ischemic cascade than LV systolic dysfunction and electrocardiographic changes. Diastolic wall strain (DWS) has been proposed as a marker of LV diastolic stiffness. Therefore, the objectives of this study were to define the relationship between DWS and coronary revascularization and to evaluate other echocardiographic parameters in patients with stable angina who were undergoing coronary angiography (CAG).<bold>Methods: </bold>Four hundred forty patients [mean age: 61 ± 10; 249 (57%) men] undergoing CAG and with normal left ventricular systolic function without regional wall motion abnormalities were enrolled. Among them, 128 (29%) patients underwent revascularization (percutaneous intervention: 117, bypass surgery: 11). All patients underwent echocardiography before CAG and the DWS was defined using posterior wall thickness (PWT) measurements from standard echocardiographic images [DWS = PWT(systole)-PWT(diastole)/PWT(systole)].<bold>Results: </bold>Patients who underwent revascularization had a significantly lower DWS than those who did not (0.26 ± 0.08 vs. 0.38 ± 0.09, p < 0.001). Age was comparable between the two groups (61 ± 9 vs. 60 ± 11, p = 0.337), but the proportion of males was significantly higher among patients who underwent revascularization (69 vs. 52%, p = 0.001). The LV ejection fraction was similar but slightly decreased (60.9 ± 5.7 vs. 62.4 ± 6.2%, p = 0.019) and the E/E' ratio was elevated (10.3 ± 4.0 vs. 9.0 ± 3.1, p < 0.001) among patients who underwent revascularization. In multiple regression analysis, lower DWS was an independent predictor of revascularization (cut-off value: 0.34; sensitivity: 89%; AUC: 0.870; SE: 0.025; p < 0.001).<bold>Conclusion: </bold>DWS, a simple parameter that can be calculated from routine 2D echocardiography, is inversely associated with the presence of coronary artery disease and the need for revascularization.
- Subjects
REVASCULARIZATION (Surgery); CORONARY heart disease surgery; ANGINA pectoris; CARDIAC imaging; CORONARY disease; PATIENTS
- Publication
BMC Cardiovascular Disorders, 2017, Vol 17, p1
- ISSN
1471-2261
- Publication type
journal article
- DOI
10.1186/s12872-017-0739-3