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- Title
Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis.
- Authors
Ai-Fang Feng; Zhong-Hui Liu; Shu-Long Zhou; Shi-Yuan Zhao; Yan-Xin Zhu; Huai-Xin Wang; Feng, Ai-Fang; Liu, Zhong-Hui; Zhou, Shu-Long; Zhao, Shi-Yuan; Zhu, Yan-Xin; Wang, Huai-Xin
- Abstract
<bold>Background: </bold>The meta-analysis was aimed to evaluate the effects of AMPD1 gene C34T polymorphism on cardiac function indexes, blood pressure and prognosis in patients with cardiovascular diseases (CVD).<bold>Methods: </bold>Eligible studies were retrieved through a comprehensive search of electronic databases and manual search. Then the high-quality studies met the rigorous inclusion and exclusion criteria, as well as related to the subject was selected for the study. Comprehensive data analyses were conducted using STATA software 12.0.<bold>Results: </bold>The study results revealed that CVD patients with CT + TT genotype of AMPD1 C34T polymorphism presented elevated left ventricular ejection fraction (LVEF) (%) and reduced left ventricular end diastolic dimension (LVEDD) (mm) as compared with CC genotype, moreover, the subgroup analysis found that the LVEF (%) was markedly higher in heart failure (HF) patients carrying CT + TT genotype than CC genotype. Besides, the systolic blood pressure (SBP) (mmHg) in CVD patients with CT + TT genotype was obviously decreased in contrast with the CC genotype. Patients suffered from HF with different genotypes (CT + TT and CC) of AMPD1 C34T polymorphism exhibited no significant differences in total survival rate and cardiac survival rate.<bold>Conclusions: </bold>Our current meta-analysis indicated that the T allele of AMPD1 gene C34T polymorphism may be correlated with LVEF, LVEDD and SBP, which plays a protective role in the cardiac functions and blood pressure in CVD patients, but had no effects on total survival rate and cardiac survival rate for HF.
- Subjects
DEAMINASES; ADENOSINE deaminase; REGULATION of blood pressure; BLOOD pressure; GENETIC polymorphisms; CARDIOVASCULAR diseases; PHYSIOLOGY; PROGNOSIS
- Publication
BMC Cardiovascular Disorders, 2017, Vol 17, p1
- ISSN
1471-2261
- Publication type
journal article
- DOI
10.1186/s12872-017-0608-0