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- Title
R‐CHOP immunochemotherapy plus surgery is associated with a superior prognosis in Chinese primary intestinal diffuse large B‐cell lymphoma.
- Authors
Zhao, Fengyi; Qin, Yan; Yang, Jianliang; Liu, Peng; He, Xiaohui; Zhou, Liqiang; Zhou, Shengyu; Gui, Lin; Zhang, Haizeng; Wang, Xin; Jiang, Shiyu; Zhong, Qiaofeng; Zhou, Yu; Shi, Yuankai
- Abstract
Aim: The aim of the study was to compare the therapeutic strategies and prognostic factors of patients with primary intestinal diffuse large B‐cell lymphoma (PI‐DLBCL). Methods: A total of 50 PI‐DLBCL patients who accepted standard first‐line treatment at National Cancer Center in China were included in this retrospective study. Survival analysis was performed to evaluate the prognostic risk factors. Results: The 3‐year overall survival (OS) and 3‐year progression‐free survival (PFS) for the entire group were 76.0% and 65.9%, respectively. Univariate analysis showed that B symptom, advanced Lugano stage, elevated LDH status, poor ECOG PS and immunochemotherapy alone were significantly correlated with a poor PFS. Elevated LDH status, poor ECOG PS, advanced Lugano stage, high IPI score and immunochemotherapy alone were significantly correlated with a poor OS. Multivariate analysis revealed that ECOG PS (P= 0.035; HR = 0.233; 95% CI, 0.060–0.905), LDH level (P = 0.010; HR = 0.223; 95% CI, 0.072–0.693) and surgery (P = 0.002; HR = 5.584; 95% CI, 1.883–16.563) were independent prognostic factors for OS. LDH level (P = 0.035; HR = 0.210; 95% CI, 0.049–0.894) and surgery (P = 0.003; HR = 6.410; 95% CI, 1.903–21.593) were independent risk factors for PFS in PI‐DLBCL. R‐CHOP immunochemotherapy combined surgery treatment was also associated with a lower rate of refractory/relapsed (R/R) disease (P = 0.004). Furthermore, stratified analysis revealed that partial resection or radical resection combined with immunochemotherapy had no significantly difference which affect OS (P = 0.338) and PFS (P = 0.207). Conclusion: R‐CHOP immunochemotherapy plus surgery was associated with a superior prognosis compared with R‐CHOP alone in Chinese PI‐DLBCL population.
- Subjects
CHINA; PROGNOSIS; CHINESE people; PROGRESSION-free survival; UNIVARIATE analysis; DIFFUSE large B-cell lymphomas; MULTIVARIATE analysis
- Publication
Asia Pacific Journal of Clinical Oncology, 2020, Vol 16, Issue 6, p385
- ISSN
1743-7555
- Publication type
Article
- DOI
10.1111/ajco.13396