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- Title
Frataxin and endothelial cell senescence in pulmonary hypertension.
- Authors
Lawrie, Allan; Francis, Sheila E.
- Abstract
Pulmonary hypertension (PH), increased blood pressure within the lungs, is classified into five diagnostic groups based on etiology, with treatment assigned on this basis. Currently, only Group 1 pulmonary arterial hypertension (PAH) and Group 4 chronic thromboembolic PH (CTEPH) have pharmacological treatments available. The role of the endothelial cell in pulmonary hypertension has long been debated, and in this issue of the JCI, Culley et al. present evidence for the reduction in frataxin expression across multiple groups of PH. Reduced frataxin expression led to endothelial cell senescence and associated with the development of PH. Removal of the senescent cells using the senolytic drug Navitoclax in multiple models of PH effectively treated PH, suggesting a new class of treatments that may work beyond Group 1 and Group 4 PH in patients with evidence of pulmonary vascular endothelial senescence.
- Subjects
CELLULAR aging; PULMONARY hypertension; ENDOTHELIAL cells; FRATAXIN; BLOOD pressure; RESEARCH; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; METALLOPROTEINS; RESEARCH funding; EPITHELIAL cells
- Publication
Journal of Clinical Investigation, 2021, Vol 131, Issue 11, p1
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI149721