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CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
Published in:
2008
By:
- Skowera, Ania;
- Ellis, Richard J.;
- Varela-Calviño, Ruben;
- Arif, Sefina;
- Guo Cai Huang;
- Van-Krinks, Cassie;
- Zaremba, Anna;
- Rackham, Chloe;
- Allen, Jennifer S.;
- Tree, Timothy I. M.;
- Min Zhao;
- Dayan, Colin M.;
- Sewell, Andrew K.;
- Unger, Wendy;
- Drijfhout, Jan W.;
- Ossendorp, Ferry;
- Roep, Bart O.;
- Peakman, Mark;
- Varela-Calviño, Ruben;
- Huang, Guo Cai
Publication type:
journal article
Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop.
Published in:
Diabetologia, 2018, v. 61, n. 3, p. 658, doi. 10.1007/s00125-017-4508-8
By:
- James, Eddie A.;
- Abreu, Joana R. F.;
- McGinty, John W.;
- Odegard, Jared M.;
- Fillié, Yvonne E.;
- Hocter, Claire N.;
- Culina, Slobodan;
- Ladell, Kristin;
- Price, David A.;
- Alkanani, Aimon;
- Rihanek, Marynette;
- Fitzgerald-Miller, Lisa;
- Skowera, Ania;
- Speake, Cate;
- Gottlieb, Peter;
- Davidson, Howard W.;
- Wong, F. Susan;
- Roep, Bart;
- Mallone, Roberto;
- on behalf of the Immunology of Diabetes Society T Cell Workshop Committee
Publication type:
Article
Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.
Published in:
Scientific Reports, 2016, p. 35332, doi. 10.1038/srep35332
By:
- Clement, Mathew;
- Pearson, James A.;
- Gras, Stephanie;
- van den Berg, Hugo A.;
- Lissina, Anya;
- Llewellyn-Lacey, Sian;
- Willis, Mark D.;
- Dockree, Tamsin;
- McLaren, James E.;
- Ekeruche-Makinde, Julia;
- Gostick, Emma;
- Robertson, Neil P.;
- Rossjohn, Jamie;
- Burrows, Scott R.;
- Price, David A.;
- Wong, F. Susan;
- Peakman, Mark;
- Skowera, Ania;
- Wooldridge, Linda
Publication type:
Article
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes.
Published in:
2018
By:
- Yeo, Lorraine;
- Woodwyk, Alyssa;
- Sood, Sanjana;
- Lorenc, Anna;
- Eichmann, Martin;
- Pujol-Autonell, Irma;
- Melchiotti, Rosella;
- Skowera, Ania;
- Fidanis, Efthymios;
- Dolton, Garry M.;
- Tungatt, Katie;
- Sewell, Andrew K.;
- Heck, Susanne;
- Saxena, Alka;
- Beam, Craig A.;
- Peakman, Mark
Publication type:
journal article
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
Published in:
2016
By:
- Cole, David K;
- Bulek, Anna M;
- Dolton, Garry;
- Schauenberg, Andrea J;
- Szomolay, Barbara;
- Rittase, William;
- Trimby, Andrew;
- Jothikumar, Prithiviraj;
- Fuller, Anna;
- Skowera, Ania;
- Rossjohn, Jamie;
- Zhu, Cheng;
- Miles, John J;
- Peakman, Mark;
- Wooldridge, Linda;
- Rizkallah, Pierre J;
- Sewell, Andrew K
Publication type:
journal article
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
Published in:
2016
By:
- Cole, David K.;
- Bulek, Anna M.;
- Dolton, Garry;
- Schauenberg, Andrea J.;
- Szomolay, Barbara;
- Rittase, William;
- Trimby, Andrew;
- Jothikumar, Prithiviraj;
- Fuller, Anna;
- Skowera, Ania;
- Rossjohn, Jamie;
- Cheng Zhu;
- Miles, John J.;
- Pealrman, Mark;
- Wooldridge, Linda;
- Rizkallah, Pierre J.;
- Sewell, Andrew K.;
- Zhu, Cheng;
- Peakman, Mark
Publication type:
journal article
Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes.
Published in:
Nature Immunology, 2012, v. 13, n. 3, p. 283, doi. 10.1038/ni.2206
By:
- Bulek, Anna M;
- Cole, David K;
- Skowera, Ania;
- Dolton, Garry;
- Gras, Stephanie;
- Madura, Florian;
- Fuller, Anna;
- Miles, John J;
- Gostick, Emma;
- Price, David A;
- Drijfhout, Jan W;
- Knight, Robin R;
- Huang, Guo C;
- Lissin, Nikolai;
- Molloy, Peter E;
- Wooldridge, Linda;
- Jakobsen, Bent K;
- Rossjohn, Jamie;
- Peakman, Mark;
- Rizkallah, Pierre J
Publication type:
Article
Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture.
Published in:
Diabetes, 2009, v. 58, n. 1, p. 138, doi. 10.2337/db08-0964
By:
- Allen, Jennifer S.;
- Pang, Karl;
- Skowera, Ania;
- Ellis, Richard;
- Rackham, Chloe;
- Lozanoska-Ochser, Biliana;
- Tree, Timothy;
- Leslie, R. David G.;
- Tremble, Jennifer M.;
- Dayan, Colin M.;
- Peakman, Mark
Publication type:
Article
Long-Lasting T Cell Responses to Biological Warfare Vaccines in Human Vaccinees.
Published in:
Clinical Infectious Diseases, 2006, v. 43, n. 1, p. 1, doi. 10.1086/504806
By:
- Allen, Jennifer S.;
- Skowera, Ania;
- Rubin, G. James;
- Wessely, Simon;
- Peakman, Mark
Publication type:
Article
β-Cell-Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure.
Published in:
Diabetes, 2015, v. 64, n. 3, p. 916, doi. 10.2337/db14-0332
By:
- Skowera, Ania;
- Ladell, Kristin;
- McLaren, James E.;
- Dolton, Garry;
- Matthews, Katherine K.;
- Gostick, Emma;
- Kronenberg-Versteeg, Deborah;
- Eichmann, Martin;
- Knight, Robin R.;
- Heck, Susanne;
- Powrie, Jake;
- Bingley, Polly J.;
- Dayan, Colin M.;
- Miles, John J.;
- Sewell, Andrew K.;
- Price, David A.;
- Peakman, Mark
Publication type:
Article
Human β-cells Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity.
Published in:
Diabetes, 2013, v. 62, n. 1, p. 205, doi. 10.2337/db12-0315
By:
- Knight, Robin R.;
- Kronenberg, Deborah;
- Min Zhao;
- Guo Cai Huang;
- Eichmann, Martin;
- Bulek, Anna;
- Wooldridge, Linda;
- Cole, David K.;
- Sewell, Andrew K.;
- Peakman, Mark;
- Skowera, Ania
Publication type:
Article
Circulating Preproinsulin Signal Peptide--Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells.
Published in:
Diabetes, 2012, v. 61, n. 7, p. 1752, doi. 10.2337/db11-1520
By:
- Kronenberg, Deborah;
- Knight, Robin R.;
- Estorninho, Megan;
- Ellis, Richard J.;
- Kester, Michel G.;
- De Ru, Arnoud;
- Eichmann, Martin;
- Huang, Guo C.;
- Powrie, Jake;
- Dayan, Colin M.;
- Skowera, Ania;
- Van Veelen, Peter A.;
- Peakman, Mark
Publication type:
Article
Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression.
Published in:
Diabetes, 2010, v. 59, n. 6, p. 1451, doi. 10.2337/db09-0503
By:
- Tree, Timothy I. M.;
- Lawson, Jennifer;
- Edwards, Hannah;
- Skowera, Ania;
- Arif, Sefina;
- Roep, Bart O.;
- Peakman, Mark
Publication type:
Article

Found: 13

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

Combinatorial detection of autoreactive CD8<sup>+</sup> T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop.

Targeted suppression of autoreactive CD8<sup>+</sup> T-cell activation using blocking anti-CD8 antibodies.

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Structural basis for the killing of human beta cells by CD8<sup>+</sup> T cells in type 1 diabetes.

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture.

Long-Lasting T Cell Responses to Biological Warfare Vaccines in Human Vaccinees.

β-Cell-Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure.

Human β-cells Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity.

Circulating Preproinsulin Signal Peptide--Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells.

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression.