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- Title
Cephalexin-Induced Acute Tubular Necrosis.
- Authors
Longstreth, Kristen L.; Robbins, Steven D.; Smavatkul, Chanigan; Doe, Nathaniel S.
- Abstract
A 24-year-old woman with a history of penicillin allergy developed reversible acute renal failure after receiving cephalexin for 4 days. The patient experienced nausea, vomiting, diarrhea, pruritus, cough, and an elevated creatinine level of 2.2 mg/dl. The patient's creatinine level continued to rise, peaking at 5.3 mg/dl on hospital day 3. Nephrotoxic acute tubular necrosis was confirmed by electron microscopy. Within 1 month of discharge from the hospital, the patient's creatinine level decreased to 0.6 mg/dl. Although the renal injury most commonly associated with the cephalosporin class of antibiotics is allergic interstitial nephritis, currently available cephalosporins infrequently can cause direct tubular toxicity.
- Subjects
ANTIBACTERIAL agents; KIDNEY diseases; NEPHROTOXICOLOGY; MICROSCOPY; GASTROINTESTINAL diseases; INTESTINAL diseases; ELECTRON microscopy; ANTI-infective agents; INTERSTITIAL nephritis
- Publication
Pharmacotherapy, 2004, Vol 24, Issue 6, p808
- ISSN
0277-0008
- Publication type
Article
- DOI
10.1592/phco.24.8.808.36069