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- Title
The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice.
- Authors
Warfield, Kelly L.; Barnard, Dale L.; Enterlein, Sven G.; Smee, Donald F.; Khaliq, Mansoora; Sampath, Aruna; Callahan, Michael V.; Ramstedt, Urban; Day, Craig W.
- Abstract
Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) -glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in mice. In the current study, the breadth of activity of UV-4B against influenza was examined ex vivo and in vivo. Efficacy of UV-4B against influenza A and B viruses was shown in primary human bronchial epithelial cells, a principal target tissue for influenza. Efficacy of UV-4B against influenza A (H1N1 and H3N2 subtypes) and influenza B was demonstrated using multiple lethal mouse models with readouts including mortality and weight loss. Clinical trials are ongoing to demonstrate safety of UV-4B and future studies to evaluate antiviral activity against influenza in humans are planned.
- Subjects
LABORATORY mice; INFLUENZA A virus; INFLUENZA B virus; ANTIVIRAL agents; CLINICAL trials
- Publication
Viruses (1999-4915), 2016, Vol 8, Issue 3, p71
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v8030071