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- Title
Self-Assembly of Proteins: Towards Supramolecular Materials.
- Authors
Yang, Liulin; Liu, Aijie; Cao, Shuqin; Putri, Rindia M.; Jonkheijm, Pascal; Cornelissen, Jeroen J. L. M.
- Abstract
The study of protein self-assembly has attracted great interest over the decades, due to the important role that proteins play in life. In contrast to the major achievements that have been made in the fields of DNA origami, RNA, and synthetic peptides, methods for the design of self-assembling proteins have progressed more slowly. This Concept article provides a brief overview of studies on native protein and artificial scaffold assemblies and highlights advances in designing self-assembling proteins. The discussions are focused on design strategies for self-assembling proteins, including protein fusion, chemical conjugation, supramolecular, and computational-aided de novo design.
- Subjects
SUPRAMOLECULAR chemistry; PROTEIN structure; MOLECULAR self-assembly; DNA folding; PEPTIDOMIMETICS
- Publication
Chemistry - A European Journal, 2016, Vol 22, Issue 44, p15570
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201601943