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- Title
The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry.
- Authors
Esteban, Concepcion Rodriguez; Capdevila, Javier; Economides, Aris N.; Pascual, Jaime; Ortiz, Angel; Belmonte, Juan Carlos Izpisua
- Abstract
Presents a study showing that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent induction of left-specific gene in the lateral plate mesoderm of the chick embryo. Initiation of gene expression in the lateral plate mesoderm by signals located in and around Hensen's node; How Car activates the expression of Nodal by antagonizing a repressive activity by bone morphogenic proteins (BMP); Conclusions.
- Subjects
CHICKEN embryos; DEVELOPMENTAL biology; EMBRYOLOGY; GENE expression
- Publication
Nature, 1999, Vol 401, Issue 6750, p243
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/45738