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- Title
Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
- Authors
Carmeliet, Peter; Dor, Yuval; Herbert, Jean-Marc; Fukumura, Dai; Brusselmans, Koen; Dewerchin, Mieke; Neeman, Michal; Bono, Françoise; Abramovitch, Rinat; Maxwell, Patrick; Koch, Cameron J.; Ratcliffe, Peter; Moons, Lieve; Jain, Rakesh K.; Collen, Désiré; Keshet, Eli
- Abstract
Presents research which showed that hypoxia and hypoglycemia reduce proliferation and increase apoptosis in wild-type embryonic stem (ES) cells. Role of hypoxia-inducible factor (HIF)-1-alpha in oxygen homeostasis; Effects in ES cells with inactivated HIF-1-alpha genes; Effects of a deficiency in HIF-1-alpha; Role of hypoxia/hypoglycemia-regulated genes; Different adaptive responses to loss of oxygen and nutrients.
- Subjects
HYPOXEMIA; HYPOGLYCEMIA; EMBRYONIC stem cells; CELL proliferation -- Molecular aspects; APOPTOSIS; MOLECULES; PHYSIOLOGY
- Publication
Nature, 1998, Vol 394, Issue 6692, p485
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/28867