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- Title
Dorsal sural nerve conduction study in vitamin B<sub>12</sub> deficiency with megaloblastic anemia.
- Authors
Turgut, Burhan; Turgut, Nilda; Akpinar, Seval; Balci, Kemal; Pamuk, Gülsüm E.; Tekgündüz, Emre; Demir, Muzaffer
- Abstract
Peripheral neuropathy is frequently observed in B12 deficiency. In spite of this, there is little knowledge about peripheral neuropathy in B12 deficiency because the severity of clinical involvement of the central nervous system clearly outweighs signs and symptoms due to peripheral nervous system involvement. We primarily investigated peripheral neuropathy with dorsal sural conduction study, which is a new method for detection of early peripheral neuropathy, in B12 deficiency with megaloblastic anemia. Conventional nerve conduction studies and tibial sensory-evoked potential (SEP) recording were also performed. Twenty-eight B12-deficient patients (15 male, 13 female, mean age 65.8 years) with megaloblastic anemia and 18 age- and sex-matched controls were included in the study. Although dorsal sural sensory nerve action potentials (SNAPs) were not recorded in 15 (54%) of 28 patients, only 9 (32%) of them were found to have polyneuropathy by conventional conduction studies. Furthermore, patients with dorsal sural SNAP had mean lower amplitude, mean longer latency, and slower velocity response when compared with controls. Twenty patients (71%) were diagnosed as having myelopathy by the combination of tibial SEP and neurological findings. Two patients whose dorsal sural SNAPs were not recorded had normal tibial SEP responses; therefore, these patients were considered to have isolated peripheral neuropathy. As a result, we conclude that dorsal sural nerve conduction study is a reliable method for detection of early peripheral neuropathy in B12 deficiency.
- Subjects
NEUROPATHY; VITAMIN B12 deficiency; MEGALOBLASTIC anemia; PERIPHERAL nervous system; EVOKED potentials (Electrophysiology)
- Publication
Journal of the Peripheral Nervous System, 2006, Vol 11, Issue 3, p247
- ISSN
1085-9489
- Publication type
Article
- DOI
10.1111/j.1529-8027.2006.00095.x