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- Title
Comprehensive Analysis and Comparison on the Codon Usage Pattern of Whole Mycobacterium tuberculosis Coding Genome from Different Area.
- Authors
Gun, Li; Yumiao, Ren; Haixian, Pan; Liang, Zhang
- Abstract
Phenomenon of unequal use of synonymous codons in<italic> Mycobacterium tuberculosis</italic> is common. Codon usage bias not only plays an important regulatory role at the level of gene expression, but also helps in improving the accuracy and efficiency of translation. Meanwhile, codon usage pattern of<italic> Mycobacterium tuberculosis</italic> genome is important for interpreting evolutionary characteristics in species. In order to investigate the codon usage pattern of the<italic> Mycobacterium tuberculosis</italic> genome, 12<italic> Mycobacterium tuberculosis</italic> genomes from different<italic> area</italic> are downloaded from the GeneBank. The correlations between G3, GC12, whole GC content, codon adaptation index, codon bias index, and so on of<italic> Mycobacterium tuberculosis</italic> genomes are calculated. The ENC-plot, relationship between A3/(A3+T3) and G3/(G3+C3), GC12 versus GC3 plot, and the RSCU of overall/separated genomes all show that the codon usage bias exists in all 12<italic> Mycobacterium tuberculosis</italic> genomes. Lastly, relationship between CBI and the equalization of ENC shows a strong negative correlation between them. The relationship between protein length and GC content (GC3 and GC12) shows that more obvious differences in the GC content may be in shorter protein. These results show that codon usage bias existing in the<italic> Mycobacterium tuberculosis </italic>genomes could be used for further study on their evolutionary phenomenon.
- Subjects
BIOCHEMISTRY; COMPARATIVE studies; DATABASES; GENE expression; GENOMES; PHENOMENOLOGY; MYCOBACTERIUM tuberculosis; PROTEINS; MEDICAL coding
- Publication
BioMed Research International, 2018, Vol 2018, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2018/3574976