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- Title
CMV‐associated collapsing focal segmental glomerulosclerosis after kidney transplant in a pediatric patient.
- Authors
Parr, Madeline F. E.; Hidalgo, Guillermo; Goldstein, Michael J.; Batal, Ibrahim; Lieberman, Kenneth V.; Amoruso, Marlene R.; Baer, Aryeh Z.; Jain, Namrata G.
- Abstract
Background: Cytomegalovirus (CMV) is a significant cause of morbidity among immunocompromised patients who have undergone kidney transplantation and is known to rarely induce collapsing focal segmental glomerulosclerosis (FSGS) among adults. Methods: We present the first reported case of CMV‐induced collapsing FSGS in a pediatric patient after kidney transplant. Results: Our patient underwent a deceased donor kidney transplant due to end‐stage renal disease secondary to lupus nephritis. Approximately 4 months after transplantation, he developed signs of worsening kidney function in the setting of CMV viremia and was found to have collapsing features of FSGS on kidney transplant biopsy. He was managed with a prompt escalation of antiviral therapy along with a reduction of immunosuppression and recovered without significant complication. At follow‐up, he continued to have undetectable CMV titers, creatinine within normal limits, and no significant proteinuria. Conclusion: This report demonstrates CMV as a cause of collapsing FSGS and should be considered among pediatric transplant recipients who present with acute kidney injury, as should early assessment of APOL1 genetic status in both donor and recipient.
- Subjects
FOCAL segmental glomerulosclerosis; CHILD patients; KIDNEY transplantation; CHRONIC kidney failure; ACUTE kidney failure; LUPUS nephritis
- Publication
Pediatric Transplantation, 2023, Vol 27, Issue 5, p1
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/petr.14535