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- Title
A new chapter in an evolving pandemic: Successful pediatric liver transplantation with SARS‐CoV‐2+ donors.
- Authors
Goss, Matthew Benjamin; Leung, Daniel Hao Bin; Pouch, Stephanie Marie; Munoz, Flor M.; Moulton, Elizabeth Andrea; Lambing, Tyler Malcolm Mccann; Koohmaraie, Sarah; Moreno, Nicolas Fernando; O'Mahony, Christine A.; Goss, John A.; Galván, Nhu Thao Nguyen
- Abstract
Background: Amid a viral pandemic with poorly understood transmissibility and pathogenicity in the pediatric patient, we report the first pediatric liver transplants utilizing allografts from SARS‐CoV‐2+ donors. Methods: We describe the outcomes of two pediatric liver transplant recipients who received organs from SARS‐CoV‐2 nucleic acid test‐positive (NAT+) donors. Data were obtained through the respective electronic medical record system and UNet DonorNet platform. Results: The first donor was a 3‐year‐old boy succumbing to head trauma. One of four nasopharyngeal (NP) swabs and 1 of 3 bronchoalveolar lavage (BAL) NAT tests demonstrated SARS‐CoV‐2 infection before organ procurement. The second donor was a 16‐month‐old boy with cardiopulmonary arrest of unknown etiology. Three NAT tests (2 NP swab/1 BAL) prior to procurement failed to detect SARS‐CoV‐2. The diagnosis was made when the medical examiner repeated 2 NP swab NATs and an archive plasma NAT, all positive for SARS‐CoV‐2. Both 2‐year‐old recipients continue to do well 8 months post‐transplant, with excellent graft function and no evidence of SARS‐CoV‐2 transmission. Conclusions: This is the first report to describe successful pediatric liver transplantation from SARS‐CoV‐2+ donors. These data reinforce the adult transplant experience and support the judicious use of SARS‐CoV‐2+ donors for liver transplantation in children. With SARS‐CoV‐2 becoming endemic, the concern for donor‐derived viral transmission must now be weighed against the realized benefit of life‐saving transplantation in the pediatric population as we continue to work toward donor pool maximization.
- Subjects
LIVER transplantation; VIRAL transmission; CHILD patients; ELECTRONIC health records; CARDIAC arrest
- Publication
Pediatric Transplantation, 2022, Vol 26, Issue 8, p1
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/petr.14407